Key Factors In The Removal Of Bacterial Endotoxins And A Cleaning Strategy

By M. L. Bernuzzi, Manager, R&D and S. Ferretti, Ph.D, R&D, Fedegari Autoclavi SpA

This article discusses the removal of bacterial endotoxins in a washing process and the need for a continuous monitoring activity according to common cleaning validation practices. Results of washing tests performed with different load materials following an effective cleaning strategy to remove microbiological soil are presented. In addition, this paper compares two different online assay methods: conductivity analysis and Total Organic Carbon analysis.