Racing 92 defeated Toulon 41-30 and outscored their opponents by six tries to three in a thrilling game.
A hat-trick from Juan imhoff for racing 92 means Toulon have now lost three of their last five games.
The game began with points from the boot - a Dan Carter penalty for racing 92, a Leigh Halfpenny penalty and Francois Trinh-Duc drop goal for Toulon.
Two tries in six minutes from Imhoff put Racing 92 15-6 aheadand thereafter they stayed ahead throughout.
Casey Laulala and Jonathan Pelissie also scored for Toulon before half-time, with a penalty from Halfpenny between the scores leaving it 20-16 at the break.
A converted try from Wenceslas Lauret, a second score of the game from Laulala another from Imhoff for his hat-trick put Racing 92 41-16 to kill the contest.
A late try from Anthony Belleau and more points from the boot of Halfpenny took his personal tally to 12, and helped Toulon narrow the margin of defeat.
Toulouse suffered a third straight defeat as they were beaten 25-20 by Lyon in an entertaining game at Matmut Stadium on Saturday.
Lyon took an early lead courtesy of a Napolioni Nalaga try in the eighth minute, and four Fred Michalak penalties saw the hosts leading 19-3 at the break.
The visitors struck back via a Sofiane Guitoune try shortly after the restart, and another from Paul Perez on the hour-mark set up a grandstand finish.
Michalak and Sebastien Bezy then traded a penalty apiece in the late stages as Lyon held on for victory.
Pau sealed their second victory of the season after they comfortably beat 2015's Top 14 champions Stade Français 23-6 at Stade du Hameau.
The hosts were 10-3 ahead at the break thanks to outside centre Conrad Smith's try and the boot of former All Black team-mate Colin Slade.
A try five minutes after the interval from Steffon Armitage gave them a handsome cushion and from there Slade's boot sealed the win.
Brive bounced back from last week's defeat at Grenoble as they ended La Rochelle's winning run, prevailing 29-28 at Stade Amédée Domenech.
It had looked like La Rochelle were heading to their fifth successive victory but a strong second-half from Brive saw them get the result.
Benjamin Lapeyre and Arnaud Mignardi scored Brive's tries while the reliable Gaetan Germain kicked two conversions and five penalties.
In reply Steeve Barry, Kini Murimurivalu and Vincent Rattez crossed for La Rochelle, who will travel home with a bonus-point to their name.
Montpellier's recent revival continued when they registered a 21-9 victory over Bayonne at Stade Jean Dauger.
The match turned into a kicking duel between Bayonne pivot Willie du Plessis, who scored all the home side's points, and his counterpart Demetri Catrakilis, who finished with an 18-point haul courtesy of six penalties.
The duo traded penalties during the opening half with Montpellier holding a slender 6-3 lead at half-time.
There was more of the same in the second half as Catrakilis slotted four more three-pointers, to Du Plessis' two, before Frans Steyn secured victory for the visitors with a place-kick of his own in the 77th minute.
In the Saturday late kick off Clermont Auvergne beat Bordeaux Begles 40-16.
After a converted try from Remi Lamerat in the 14th minute the first-half was dominated by points from the boots of Morgan parra for Clermont, and Lionel Beauxis for Bordeaux.
The second-half saw Clermont score four tries to pull away through Paul Jedrasiak, Davit Zirakshvilliand a brace for David Strettle.
Parra kicked 15 points, whilst Beauxis notched 11 with his boot. Metuisela Talebula scored what was to prove a consolation try for Bordeaux.
Castres Olympique scored seven tries in comfortably defeating Grenoble 46-9.
In the opening half Rory Kockott, Mathieu Babillot and Jody Jenneker also crossed the whitewash for Castres, whilst Kockott notched a penalty too.
The second-half saw the points keep flooding in for Castres, Afusipa Taumoepeau scoring, and then inside the last ten minutes Victor Moreaux, Marc-Antoine Rallier and Thomas Comezou all got in on the act.
Benjamin Urdapilleta kicked four conversions across the game for the hosts.
Three first-half penalties from Gilles Bosch were the only points scored by Grenoble.