Issue 74, 2016
From the journal:

Chemical Communications

“Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry†

Liyang Shi,a   Yuanyuan Han,b   Jöns Hilborna  and  Dmitri Ossipov ORCID logo *a  

* Corresponding authors

a Science for Life Laboratory, Division of Polymer Chemistry, Department of Chemistry-Ångström, Uppsala University, Uppsala, Sweden
E-mail: dmitri.ossipov@kemi.uu.se

b Department of Engineering Sciences, Uppsala University, Uppsala, Sweden

Abstract

We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium–bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.

Graphical abstract: “Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry

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Article information

DOI
https://doi.org/10.1039/C6CC05565F
Article type
Communication
Submitted
05 Jul 2016
Accepted
15 Aug 2016
First published
15 Aug 2016

Chem. Commun., 2016,52, 11151-11154

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“Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry

L. Shi, Y. Han, J. Hilborn and D. Ossipov, Chem. Commun., 2016, 52, 11151 DOI: 10.1039/C6CC05565F

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