8 Prescription Meds that Make It Harder to Lose Weight


Among the drugs that block weight loss are:

• Beta-blockers: metoprolol, atenolol, carvedilol, and propranolol

• Antidepressants: amitriptyline (Elavil), nortriptyline (Pamelor), doxepin, paroxetine (Paxil), trazodone, and others

• Steroids such as prednisone and hydrocortisone (but not inhaled or nasal steroids for allergies)

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• Antihistamines—diphenhydramine (Benadryl), fexofenadine (Allegra), cetirizine (Zyrtec), cyproheptadine (Periactin), and others; note that the widely used sleep aid Tylenol PM contains diphenhydramine

• Lyrica for fibromyalgia and pain

• Valproic acid (Depakote) for seizures

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• Actos and Avandia for prediabetes and diabetes

• Insulin—injectable insulin can actually be responsible for astounding quantities of weight gain. 

Obviously, attempts to reduce or eliminate these drugs should be undertaken with the cooperation of your health care provider, as most of these drugs should not just be stopped. Discuss with your doctor how and why you would like to do this. If you encounter resistance or ignorance, or a refusal to discuss or answer questions, find a health care practitioner who will work with you.

Don’t be surprised if your doctor denies that these drugs block weight loss or cause weight gain, but such associations have been demonstrated repeatedly in clinical trials. And recognize that many of these drugs were unknowingly prescribed to treat the consequences of wheat and grain consumption in the first place, with many conditions receding with your new wheat and grain-free lifestyle.

Adapted from Wheat Belly 10-Day Grain Detox