Issue 61, 2015
From the journal:

Chemical Communications

Synthesis of disulfide-based biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells†

Jonas G. Croissant,‡a   Chiara Mauriello-Jimenez,‡a   Marie Maynadier,c   Xavier Cattoën,d   Michel Wong Chi Man,a   Laurence Raehm,a   Olivier Mongin,e   Mireille Blanchard-Desce,f   Marcel Garcia,b   Magali Gary-Bobo,*b   Philippe Maillardg  and  Jean-Olivier Durand*a  

* Corresponding authors

a Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM cc 1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France
E-mail: durand@um2.fr

b Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, UM 1, UM 2-Faculté de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 05, France
E-mail: magali.gary-bobo@inserm.fr

c NanoMedSyn, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 05, France

d Institut Néel, CNRS and Université Grenoble-Alpes, 38042 Grenoble, France

e Institut des Sciences Chimiques de Rennes, CNRS UMR 6226 Université Rennes 1 Campus Beaulieu F-35042 Rennes Cedex, France

f University Bordeaux, Institut des Sciences Moléculaires, UMR CNRS 5255, 351 Cours de la Libération, F-33405 Talence Cedex, France

g Institut Curie, UMR 9187-U 1196, CMIB, CNRS-INSERM, Centre Universitaire, F-91405 Orsay, France

Abstract

Biodegradable bridged silsesquioxane (BS) nanomaterials for two-photon-excited (TPE) imaging and therapy of breast cancer cells were described. A versatile synthesis was developed to design monodisperse tetra-alkoxysilylated diamino-diphenylbutadiene or Zn-porphyrin-based nanospheres of 30 to 50 nm.

Graphical abstract: Synthesis of disulfide-based biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells

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Article information

DOI
https://doi.org/10.1039/C5CC03736K
Article type
Communication
Submitted
05 May 2015
Accepted
17 Jun 2015
First published
18 Jun 2015

Chem. Commun., 2015,51, 12324-12327

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Synthesis of disulfide-based biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells

J. G. Croissant, C. Mauriello-Jimenez, M. Maynadier, X. Cattoën, M. Wong Chi Man, L. Raehm, O. Mongin, M. Blanchard-Desce, M. Garcia, M. Gary-Bobo, P. Maillard and J. Durand, Chem. Commun., 2015, 51, 12324 DOI: 10.1039/C5CC03736K

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