Issue 24, 2015
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed chemoselective synthesis of indane-1,3-dione derivatives via tert-butyl isocyanide insertion†

Huaqing Duan,a   Zhong Chen,a   Li Han,b   Yulin Feng,c   Yongming Zhu*a  and  Shilin Yang*a  

* Corresponding authors

a College of Pharmaceutical Science, Soochow University, 199 Ren-ai Road, Suzhou 215123, China
E-mail: zhuyongming@suda.edu.cn, yangshilin@suda.edu.cn

b Zhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, 80 Changjiang Road, Nanyang 473000, China

c Jiangxi University of Traditional Chinese Medicine, 56 Yangming Road, Nanchang 330006, China

Abstract

A simple and efficient strategy for the synthesis of indane-1,3-dione derivatives through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed. In addition, by applying this protocol as the key step, indenopyrazole derivatives can be easily synthesized in high yields in a one-pot procedure. This methodology is tolerant of a wide range of substrates and applicable to library synthesis.

Graphical abstract: Palladium-catalyzed chemoselective synthesis of indane-1,3-dione derivatives via tert-butyl isocyanide insertion

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Article information

DOI
https://doi.org/10.1039/C5OB00472A
Article type
Paper
Submitted
10 Mar 2015
Accepted
11 May 2015
First published
11 May 2015

Org. Biomol. Chem., 2015,13, 6782-6788

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Palladium-catalyzed chemoselective synthesis of indane-1,3-dione derivatives via tert-butyl isocyanide insertion

H. Duan, Z. Chen, L. Han, Y. Feng, Y. Zhu and S. Yang, Org. Biomol. Chem., 2015, 13, 6782 DOI: 10.1039/C5OB00472A

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