A novel sensor for sensitive determination of atropine based on a Co3O4-reduced graphene oxide modified carbon paste electrode

Hasan Bagheri; Seyedeh Maryam Arab; Hosein Khoshsafar; Abbas Afkhami

doi:10.1039/C5NJ00133A

A novel sensor for sensitive determination of atropine based on a Co₃O₄-reduced graphene oxide modified carbon paste electrode†

Hasan Bagheri,*^a Seyedeh Maryam Arab,^b Hosein Khoshsafar^c and Abbas Afkhami^d

* Corresponding authors

^a Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
E-mail: h_bagheri82@hotmail.com, h.bagheri82@gmail.com

^b Research Center of Shaygan Shimi Chemical Co., Hamedan, Iran

^c Young Researchers Club, Hamedan Branch, Islamic Azad University, Hamedan, Iran

^d Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran

Abstract

This paper has presented a novel strategy to carry out direct and sensitive determination of atropine in complex matrices based on the Co₃O₄-graphene modified carbon paste electrode. This novel nanostructure was characterized by different spectroscopic and electrochemical techniques including scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and electrochemical impedance spectroscopy. The fabricated electrochemical sensor showed good electrochemical response towards atropine. Under the optimized conditions, the calibration curve for atropine concentration was linear in the range from 0.1 to 3.2 μmol L⁻¹ with the detection limit of 0.03 μmol L⁻¹. In addition, the practical analytical performance of the sensor was examined by evaluating the selective detection of atropine in biological fluids and pharmaceutical samples with satisfied recovery. Therefore, the prepared sensor may hold great promise for fast, simple and sensitive detection and biomedical analysis of atropine in various real samples.

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Article information

DOI: https://doi.org/10.1039/C5NJ00133A
Article type: Paper
Submitted: 17 Jan 2015
Accepted: 06 Mar 2015
First published: 06 Mar 2015

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New J. Chem., 2015,39, 3875-3881

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A novel sensor for sensitive determination of atropine based on a Co₃O₄-reduced graphene oxide modified carbon paste electrode

H. Bagheri, S. M. Arab, H. Khoshsafar and A. Afkhami, New J. Chem., 2015, 39, 3875 DOI: 10.1039/C5NJ00133A

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