1 October 2014

Placement - Appendix 3B and Cleansing Notice

Antisense Therapeutics Limited ("ANP" or the "Company") is pleased to advise that as part of a A$1.0 million private placement (Placement) as per ASX announcement on 25 September

2014, it has today issued the first 7,913,043 new ordinary fully paid shares at 11.5 cents per share to sophisticated and professional investors. As previously advised, the Board's participation in the Placement is conditional on Company receiving shareholder approval at the

upcoming Annual General Meeting.

Utilising part of the Company's available 15% placement capacity under ASX Listing 7.1,

622,364 Shares were issued to Destum Partners, Inc as consideration for fees payable to them by the Company to date. In addition, the Company has utilised part of its available 10% placement capacity under ASX Listing Rule 7.1A for the issue of 7,290,679 shares to

sophisticated and professional investors.

In accordance with ASX Listing Rule 3.10.5A the following information is provided to the ASX

in relation to the issue of 7,290,679 shares pursuant to ASX Listing Rule 7.1A.

1. The issue of 7,290,679 shares pursuant to ASX Listing Rule 7.1A raised approximately

$838,428 and diluted the voting power of existing shareholders by 4.8%.

2. The Company elected to issue the shares as a placement under Listing Rule 7.1A rather than a pro rata issue (or other type of issue) due to the strong support from sophisticated and professional investors and the cost and timing benefits of a private placement. The Company is also conducting a Share Purchase Plan in conjunction with the Placement as per ASX announcement on 25 September 2014.

3. There was no underwriting agreement in connection with the Placement.

4. The Company incurred a broker commission fee equal to 6% of funds raised.

Please see attached Appendix 3B and notice pursuant to Section 708A(5)(e) of the

Corporations Act 2001 (Cth) in relation to the issue of shares.

Contact Information:

Website: www.antisense.com.au

Company Secretary: Phillip Hains +61 (0)3 9824 5254

Antisense Therapeutics Limited (ASX: ANP) is an Australian publicly listed biopharmaceutical drug discovery and development company. Its mission is to create, develop and commercialise second generation antisense pharmaceuticals for large unmet markets. ANP has 4 products in its development pipeline that it has in-licensed from Isis Pharmaceuticals Inc., world leaders in antisense drug development and commercialisation - ATL1102 (injection) which has successfully completed a Phase II efficacy and safety trial, significantly reducing the number of brain lesions in patients with relapsing- remitting multiple sclerosis (RRMS) , ATL1103 a second-generation antisense drug designed to block GHr production which in a Phase II clinical trial, successfully reduced blood IGF-I levels in patients with the growth disorder acromegaly, ATL1102 (inhaled) which is at the pre-clinical research stage as a potential treatment for asthma and ATL1101 a second-generation antisense drug at the pre-clinical stage being investigated as a potential treatment for cancer.

6 WALLACE AVENUE, TOORAK VIC 3142 AUSTRALIA TEL . +61 (3) 9827 8999 FAX +61 (3) 9827 1166 WEB WWW.ANTISENSE.COM.AU ANTISENSE THERAPEUTICS LIMITED

ABN 41 095 060 745

Appendix 3B

Rule 2.7, 3.10.3, 3.10.4, 3.10.5

New Issue Announcement, Application for Quotation of Additional Securities and Agreement

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 01/07/96 Origin: Appendix 5 Amended 01/07/98, 01/09/99, 01/07/00, 30/09/01, 11/03/02, 01/01/03, 24/10/05, 01/08/12, 04/03/13

Name of Entity

Antisense Therapeutics Limited (ASX: ANP)

ABN

41 095 060 745

We (the entity) give ASX the following information.

Part 1 ‐ All issues

You must complete the relevant sections (attach sheets if there is not enough space).


1 +Class of +securities issued or to be issued
Ordinary Fully Paid Shares (ANP)

2 Number of +securities issued or to be issued (if known) or maximum number which may be issued
7,913,043

3 Principal terms of the +securities (e.g. if options, exercise price and expiry date; if partly paid +securities, the amount outstanding and due dates for payment; if +convertible securities, the conversion price and dates for conversion)
Pari passu with existing Ordinary Fully Paid Shares (ANP)

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 1

4 Do the +securities rank equally in all respects from the +issue date with an existing +class of quoted +securities?
If the additional +securities do not rank equally, please state:

the date from which they do

the extent to which they participate for the next dividend, (in the case of a trust, distribution) or interest payment

the extent to which they do not rank equally, other than in relation to the next dividend, distribution or interest payment

6 Purpose of the issue
(If issued as consideration for the acquisition of assets, clearly identify those assets)
Yes (ANP)

a. Private Placement
b. In payment of services provided.

6a Is the entity an +eligible entity that has obtained security holder approval under rule 7.1A?

If Yes, complete sections 6b - 6h in relation to the +securities the subject of this Appendix 3B, and comply with section 6i

Yes

6b The date the security holder resolution under rule 7.1A was passed
1st November 2013

6c Number of +securities issued without security holder approval under rule 7.1
622,364

6d Number of +securities issued with security holder approval under rule
7.1A
7,290,679

6e Number of +securities issued with security holder approval under rule 7.3, or another specific security holder approval (specify date of meeting)
Nil

6f Number of +securities issued under an exception in rule 7.2
Nil

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 2


6g If +securities issued under rule 7.1A, was issue price at least 75% of 15 day VWAP as calculated under rule 7.1A.3? Include the +issue date and both values. Include the source of the VWAP calculation.
Yes
VWAP: $0.1266
75% of VWAP: $0.095
Issue Price: $0.115
Issue Date: 1 October 2014
VWAP Source: IRESS Market Technology

6h If +securities were issued under rule
7.1A for non‐cash consideration, state date on which valuation of consideration was released to ASX Market Announcements
N/A

6i Calculate the entity's remaining issue capacity under rule 7.1 and rule 7.1A - complete Annexure 1 and release to ASX Market Announcements
Refer to the attached Appendix 1
7 +Issue dates

Note: The issue date may be prescribed by ASX (refer to the definition of issue date in rule 19.12). For example, the issue date for a pro rata entitlement issue must comply with the applicable timetable in Appendix 7A.

Cross reference: item 33 of Appendix 3B.

1 October 2014
8 Number and +class of all +securities quoted on ASX (including the

+securities in section 2 if applicable)

9 Number and +class of all +securities not quoted on ASX (including the

+securities in section 2 if applicable)

10 Dividend policy (in the case of a trust, distribution policy) on the increased capital (interests)

N/A

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 3

Part 2 ‐ Pro rata issue


11 Is security holder approval required? N/A

12 Is the issue renounceable or non‐
renounceable?

N/A


13 Ratio in which the +securities will be offered

N/A


14 +Class of +securities to which the offer relates

N/A


15 +Record date to determine entitlements

N/A


16 Will holdings on different registers (or subregisters) be aggregated for calculating entitlements?

N/A


17 Policy for deciding entitlements in relation to fractions

N/A


18 Names of countries in which the entity has security holders who will not be sent new offer documents

Note: Security holders must be told how their entitlements are to be dealt with.

Cross reference: rule 7.7.

N/A


19 Closing date for receipt of acceptances or renunciations

N/A


20 Names of any underwriters N/A

21 Amount of any underwriting fee or commission

N/A


22 Names of any brokers to the issue N/A

23 Fee or commission payable to the broker to the issue

N/A


24 Amount of any handling fee payable to brokers who lodge acceptances or renunciations on behalf of security holders

N/A


25 If the issue is contingent on security holders' approval, the date of the meeting

N/A

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 4


26 Date entitlement and acceptance form and offer documents will be sent to persons entitled

N/A


27 If the entity has issued options, and the terms entitle option holders to participate on exercise, the date on which notices will be sent to option holders

N/A


28 Date rights trading will begin (if applicable)

N/A


29 Date rights trading will end (if applicable)

N/A


30 How do security holders sell their entitlements in full through a broker?

N/A


31 How do security holders sell part of their entitlements through a broker and accept for the balance?

N/A


32 How do security holders dispose of their entitlements (except by sale through a broker)?

N/A


33 +Issue date N/A

Part 3 ‐ Quotation of securities

You need only complete this section if you are applying for quotation of securities

34 Type of +securities
(tick one)
(a) +Securities described in Part 1
(b) All other +securities Example: restricted securities at the end of the escrowed period, partly paid securities that become fully paid, employee incentive share securities when restriction ends, securities issued on expiry or conversion of convertible securities

Entities that have ticked box 34(a)

Additional securities forming a new class of securities

Tick to indicate you are providing the information or documents

35 If the +securities are +equity securities, the names of the 20 largest holders of the additional

+securities, and the number and percentage of additional +securities held by those holders

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 5

36 If the +securities are +equity securities, a distribution schedule of the additional +securities setting out the number of holders in the categories
1 ‐ 1,000
1,001 ‐ 5,000
5,001 ‐ 10,000
10,001 ‐ 100,000
100,001 and over
37 A copy of any trust deed for the additional +securities

Entities that have ticked box 34(b)


38 Number of +securities for which

+quotation is sought


39 +Class of +securities for which quotation is sought

40 Do the +securities rank equally in all respects from the +issue date with an existing +class of quoted +securities?
If the additional +securities do not rank equally, please state:

the date from which they do

the extent to which they participate for the next dividend, (in the case of a trust, distribution) or interest payment

the extent to which they do not rank equally, other than in relation to the next dividend, distribution or interest payment


41 Reason for request for quotation now

Example: In the case of restricted securities, end of restriction period

(if issued upon conversion of another

+security, clearly identify that other

+security)

42 Number and +class of all +securities quoted on ASX (including the

+securities in clause 38)

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 6

Quotation agreement

1 +Quotation of our additional +securities is in ASX's absolute discretion. ASX may quote the +securities on any conditions it decides.
2 We warrant the following to ASX.

The issue of the +securities to be quoted complies with the law and is not for an illegal purpose.

There is no reason why those +securities should not be granted +quotation.

An offer of the +securities for sale within 12 months after their issue will not require disclosure under section 707(3) or section 1012C(6) of the Corporations Act.
Note: An entity may need to obtain appropriate warranties from subscribers for the securities in order to be able to give this warranty

Section 724 or section 1016E of the Corporations Act does not apply to any applications received by us in relation to any +securities to be quoted and that no‐one has any right to return any +securities to be quoted under sections 737, 738 or 1016F of the Corporations Act at the time that we request that the +securities be quoted.

If we are a trust, we warrant that no person has the right to return the +securities to be quoted under section 1019B of the Corporations Act at the time that we request that the +securities be quoted.

3 We will indemnify ASX to the fullest extent permitted by law in respect of any claim, action or expense arising from or connected with any breach of the warranties in this agreement.
4 We give ASX the information and documents required by this form. If any information or document is not available now, we will give it to ASX before +quotation of the +securities begins. We acknowledge that ASX is relying on the information and documents. We warrant that they are (will be) true and complete.

Sign here:
Company Secretary
Print name: Mr Phillip Hains

The CFO Solution

1 October 2014

Date Wednesday, 1 October 2014

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 7

Appendix 3B - Annexure 1 Calculation of placement capacity under rule 7.1 and rule 7.1A for eligible entities

Introduced 01/08/12 Amended 04/03/13

Part 1

Rule 7.1 - Issues exceeding 15% of capital

Step 1: Calculate "A", the base figure from which the placement capacity is calculated

Insert number of fully paid +ordinary securities on issue

12 months before the +issue date or date of agreement to issue

144,095,128

Add the following:

• Number of fully paid +ordinary securities issued in that 12 month period under an exception in rule 7.2

• Number of fully paid +ordinary securities issued in that 12 month period with shareholder approval

• Number of partly paid +ordinary securities that became fully paid in that 12 month period

Note:

• Include only ordinary securities here - other classes of equity securities cannot be added

• Include here (if applicable) the securities the subject of the Appendix 3B to which this form is annexed

• It may be useful to set out issues of securities on different dates as separate line items

1,000

Subtract the number of fully paid +ordinary securities cancelled during that 12 month period

Nil

"A"

144,096,128

Step 2: Calculate 15% of "A"

"B"

0.15

[Note: this value cannot be changed]

Multiply "A" by 0.15

21,614,419

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 8

Step 3: Calculate "C", the amount of placement capacity under rule 7.1 that has already been used

Insert number of +equity securities issued or agreed to be issued in that 12 month period not counting those

issued:

• Under an exception in rule 7.2

• Under rule 7.1A

• With security holder approval under rule 7.1 or rule

7.4

Note:

• This applies to equity securities, unless specifically excluded - not just ordinary securities

• Include here (if applicable) the securities the subject of the

Appendix 3B to which this form is annexed

• It may be useful to set out issues of securities on different dates as separate line items

845,820

"C"

845,820

Step 4: Subtract "C" from ["A" x "B"] to calculate remaining placement capacity under rule 7.1

"A" x 0.15

Note: number must be same as shown in Step 2

21,614,419

Subtract "C"

Note: number must be same as shown in Step 3

845,820

Total ["A" x 0.15] - "C"

20,768,599

[Note: this is the remaining placement capacity under rule 7.1]

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 9

Part 2

Rule 7.1A - Additional placement capacity for eligible entities

Step 1: Calculate "A", the base figure from which the placement capacity is calculated

"A"

Note: number must be same as shown in Step 1 of Part 1

144,096,128

Step 2: Calculate 10% of "A"

"D"

0.10

Note: this value cannot be changed

Multiply "A" by 0.10

14,409,613

Step 3: Calculate "E", the amount of placement capacity under rule 7.1A that has already been used

Insert number of +equity securities issued or agreed to be issued in that 12 month period under rule 7.1A

Notes:

• This applies to equity securities - not just ordinary securities

• Include here - if applicable - the securities the subject of the

Appendix 3B to which this form is annexed

• Do not include equity securities issued under rule 7.1 (they must be dealt with in Part 1), or for which specific security holder approval has been obtained

• It may be useful to set out issues of securities on different dates as separate line items

7,290,679

"E"

7,290,679

Step 4: Subtract "E" from ["A" x "D"] to calculate remaining placement capacity under rule 7.1A

"A" x 0.10

Note: number must be same as shown in Step 2

14,409,613

Subtract "E"

Note: number must be same as shown in Step 3

7,290,679

Total ["A" x 0.10] - "E"

7,118,934

Note: this is the remaining placement capacity under rule

7.1A

+ See chapter 19 for defined terms.

04/03/2013 Appendix 3B Page 10

ASX ANNOUNCEMENT

Notice Under Section 708A(5) of the Corporations Act

[ASX Code: ANP]

Wednesday 1st October 2014

This notice is given under paragraph (5)(e) of section 708A of the Corporations Act.

Type:

Shares (ANP)

Class/Description:

Ordinary Fully Paid Shares

(ANP)

ASX Code:

ANP

Date of Issue

1 October 2014

Number Issued:

7,913,043

Antisense Therapeutics Limited (the Company) intends to apply to Australian Stock

Exchange Limited for quotation of the above securities.

Accordingly the Company gives notice under section 708A(5)(e) of the Corporations

Act 2001 (Cth) (the "Corporations Act") that:

1. the abovementioned ordinary shares were issued without disclosure to investors under Part 6D.2 of the Corporations Act;

2. as at the date of this notice the Company has complied with:

(i) the provisions of Chapter 2M Corporations Act as they apply to the

Company; and

(ii) section 674 Corporations Act; and

3. as at the date of this notice there is no "excluded information" (as defined in subsection 708A(7) of the Corporations Act) which is required to be disclosed by the Company.

For and on behalf of the Company,

Phillip Hains

Company Secretary

6 WALLACE AVENUE, TOORAK VIC 3142 AUSTRALIA TEL . +61 (3) 9827 8999 FAX +61 (3) 9827 1166 WEB WWW.ANTISENSE.COM.AU ANTISENSE THERAPEUTICS LIMITED

ABN 41 095 060 745

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