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Leslie Mann is joining the cast of New Line’s “Vacation” sequel opposite Ed Helms and Christina Applegate.

Shooting is set to start next week in Louisiana with John Francis Daley and Jonathan Goldstein making their directorial debut from their script. Helms is starring as Rusty Griswold, the grown-up son of Clark Griswold (portrayed by Chevy Chase in the 1983 film), who takes a family trip similar to the one he took as a boy.

Mann will play Rusty’s sister Audrey Griswold, who was played by Dana Barron in the 1983 original. Skyler Gisondo and Steele Stebbins have been tapped as Rusty Griswold’s sons in the reboot and Chris Hemsworth and Charlie Day are in negotiations to appear.

Chase and Beverly D’Angelo, who played Clark Griswold’s wife in the original, are on board to appear.

Chris Bender and David Dobkin are producing. Jeff Kleeman is exec producing.

Mann last starred in the comedy “The Other Woman” with Cameron Diaz and Kate Upton. She is repped by CAA.

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The news was first reported by The Hollywood Reporter.