Issue 36, 2014

MIDA as a simple and highly efficient ligand for palladium-catalyzed Hiyama cross-coupling of aryl halides

Abstract

N-Methyliminodiacetic acid (MIDA) as a simple, air stable and water-soluble ligand has been used in the palladium-catalyzed Hiyama cross-coupling reaction of trimethoxyphenylsilane with aryl halides. The yield of the corresponding Hiyama coupling products is high up to around 90% in water and isopropanol under an ambient atmosphere in the presence of KOH and NaF.

Graphical abstract: MIDA as a simple and highly efficient ligand for palladium-catalyzed Hiyama cross-coupling of aryl halides

Article information

Article type
Paper
Submitted
22 May 2014
Accepted
24 Jul 2014
First published
11 Aug 2014

Org. Biomol. Chem., 2014,12, 7136-7139

MIDA as a simple and highly efficient ligand for palladium-catalyzed Hiyama cross-coupling of aryl halides

M. Guo, L. Qi, Q. Zhang, Z. Zhu, W. Li and X. Li, Org. Biomol. Chem., 2014, 12, 7136 DOI: 10.1039/C4OB01056F

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