Issue 45, 2014
From the journal:

Chemical Communications

Design of tetraplex specific ligands: cyclic naphthalene diimide†

Yugo Esaki,a   Md. Monirul Islam,a   Satoshi Fujii,b   Shinobu Satoac  and  Shigeori Takenaka*ac  

* Corresponding authors

a Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
E-mail: shige@che.kyutech.ac.jp
Fax: +81-93-884-3322

b Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka 820-8502, Japan

c Research Center for Bio-microsensing Technology, Kyushu Institute of Technology, Fukuoka 804-8550, Japan

Abstract

Cyclic naphthalene diimide 1 bound to hybrid-type tetraplex DNA from 5′-AGGG(TTAGGG)3-3′ (K = 8.6 × 106 M−1) with 260-fold greater affinity than binding to a double stranded oligonucleotide consisting of 5′-GGG AGG TTT CGC-3′ and 3′-CCC TCC AAA GCG-5′ (nK = 3.3 × 104 M−1) with 0.5 μM of IC50 for telomerase activity.

Graphical abstract: Design of tetraplex specific ligands: cyclic naphthalene diimide

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Article information

DOI
https://doi.org/10.1039/C4CC01005A
Article type
Communication
Submitted
07 Feb 2014
Accepted
11 Apr 2014
First published
11 Apr 2014

Chem. Commun., 2014,50, 5967-5969

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Design of tetraplex specific ligands: cyclic naphthalene diimide

Y. Esaki, Md. M. Islam, S. Fujii, S. Sato and S. Takenaka, Chem. Commun., 2014, 50, 5967 DOI: 10.1039/C4CC01005A

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